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Opium . . . The ancient Sumerians cultivated the opium poppy; the great Islamic physician Avicenna died of an accidental, self-administered overdose in 1037 C.E.; in the 17th century, Thomas Sydenham wrote that no other pain reliever "is so universal and so efficacious as opium." Opium was banned by imperial edict in China in 1799, but the trade had been so profitable to the East India Company that the British fought two "Opium Wars" to force the Chinese again to allow its importation. In the 20th century, beginning with the International Congress of 1912, many of the world's nations placed severe restrictions on the use of opium and its derivatives; these sanctions failed to end narcotic smuggling and abuse but contributed to the demonization of these drugs. By the 1950s, fears of addiction led many physicians and nurses to limit opioid use despite its great value in relieving the suffering of patients in severe and chronic pain.
Opioids . . . In the second half of the 20th century, researchers have learned to describe the actions of opioid drugs in the human body, discovered the endogenous substances and receptors that replicate their effects, clarified the difference between addiction and dependence on a drug for a medical need, and developed new formulations and methods of delivery. In 1982 the World Health Organization launched a global program to advocate the use of strong opioids for the management of cancer pain, and their use in noncancer pain has improved the lives of many. And yet, patients and clinicians are troubled by the enigma of the opioids, the Janus drugs that show us two faces: the euphoria of pain relief and the horror of addiction.
The target audience for this multidisciplinary symposium includes physicians, nurses, pharmacists, and practitioners who work with patients in pain, as well as all researchers interested in the history of pain medicine. As a participant, you will hear distinguished historians, scientists, physicians, and other scholars describe the history of opioid use in patient care; the history of opioid research, findings about the chemistry and pharmacology of both exogenous and endogenous opioids, and the impact of this research on clinical practice; and the new rationale of international health policy regarding medical use of opioids. As a group, we will discuss the relevance of this history to pain management today.
The Setting
The UCLA Faculty Center is a modern facility on the campus of this internationally recognized research university. As a symposium participant, you will enjoy state-of-the-art audiovisual capabilities and excellent catering as well as the delightful California climate on the center's several patios. On Friday evening you will be offered free bus transportation to the world-famous Getty Center. After the conference adjourns at noon on Saturday, you may tour the John C. Liebeskind History of Pain Collection, visit one of LA's many museums or theme parks, or relax on the beach.
All symposium proceedings will be in English.
This symposium is presented by the UCLA John C. Liebeskind History of Pain Collection and sponsored by the Office of CME, David Geffen School of Medicine, UCLA, and the UCLA Neuropsychiatric Institute.
Accreditation Statement
CME Sponsor: The Office of Continuing Medical Education, David Geffen School of Medicine, UCLA, is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians.
Accreditation: The Office of Continuing Medical Education, David Geffen School of Medicine, UCLA, designates this continuing medical education activity for up to 8 hours in Category I credit towards the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the educational activity.
Disclosure: The FDA has issued a concept paper which classifies commercial support of scientific and educational programs as promotional unless it can be affirmed that the program is "truly independent" and free of commercial influence. In addition to independence, the FDA requires that non-promotional, commercially supported education be objective, balanced, and scientifically rigorous. This policy further states that all potential conflicts of interest of the CME staff and faculty be fully disclosed to the program's participants. We at UCLA fully endorse the letter and spirit of this concept.
In compliance with this policy, the program will have disclosed to it any potential conflict(s) of interest related to the content of presentations made by all faculty participating in sponsored or jointly sponsored programs by the David Geffen School of Medicine, UCLA.
UCLA Co-Chairs:
Joel T. Braslow, MD, PhD
Associate Professor in Residence, Psychiatry and Biobehavioral Sciences, and History; Director, UCLA Neuroscience History Archives
Marcia L. Meldrum, PhD
Lecturer, Department of History; Co-Director, John C. Liebeskind History of Pain Collection
Katharine E.S. Donahue, MLS
Head, History & Special Collections Division, Louise M. Darling Biomedical Library; Co-Director, John C. Liebeskind History of Pain Collection
Friday, August 23, 2002
8 - 8:40 a.m.
Registration and continental breakfast
8:40 - 9 a.m.
Welcome to UCLA and Opening Remarks
Joel T. Braslow, MD, PhD
Associate Professor in Residence, Psychiatry and Biobehavioral Sciences, UCLA
John D. Loeser, MD
Past IASP President; Professor, Neurological Surgery, University of Washington
9 - 10 a.m.
Session I: Before the 20th Century
Walton G. Schalick III, MD, PhD
Assistant Professor, Pediatrics, Washington University/St. Louis
on opium and pain relief in medieval Europe
Martha Stoddard Holmes, PhD
Assistant Professor, Literature, California State University/San Marcos
on pain management and palliative care in the 19th century
10 - 10:30 a.m.
Discussion and coffee break
10:30 - 11:30 a.m.
Session II: The Opiate Molecule, 1900-2000
Caroline J. Acker, PhD
Assistant Professor, History, Carnegie Mellon University, Pittsburgh
on the search for a nonaddicting analgesic
Kenner C. Rice, PhD
Drug Design and Synthesis Chief, Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
on the laboratory synthesis of morphine
11:30 a.m. - 12 noon
Discussion
12 noon - 1:15 p.m.
Lunch with the speakers
1:15 - 2:15 p.m.
Session III: The Opiate Receptors, 1969-1990
Huda Akil, PhD
Gardner C. Quarton Professor of Neurosciences and Professor, Psychiatry, University of Michigan
on the phenomenon of stimulation-produced analgesia
Robert Kanigel
Professor, Science Writing and Humanistic Studies, Massachusetts Institute of Technology
on the isolation of the opiate receptors
2:15 - 2:45 p.m.
Discussion and coffee break
2:45 - 4:15 p.m.
Session IV: Clinical Research, 1950-2001
David Clark, PhD
Professor and Chair, Medical Sociology, University of Sheffield
Christina Faull, MD
Medical Director, St. Mary's Hospice, Birmingham
on palliative care research on opioid use
Michael Cousins, MD
Past IASP President; Professor and Head, Anaesthesia and Pain Management, University of Sydney
on pain management with spinal opioids
4:15 - 4:45 p.m.
Discussion
4:45 - 6 p.m.
Reception and buffet
6 p.m.
Buses leave for the Getty Center
9 p.m.
Buses return from the Getty Center
Saturday, August 24, 2002
8:30 - 9 a.m.
Continental breakfast
9 - 10:30 a.m.
Session V: A New Paradigm and a New Policy, 1982-2001
Marcia L. Meldrum, PhD
Co-Director, John C. Liebeskind History of Pain Collection, UCLA
on the emergence of a new paradigm
Mark Swerdlow, DM
Founder, Intractable Pain Society; Director Emeritus, Northwest Regional Pain Relief Centre, Manchester
on the WHO Cancer Pain Relief Programme
June L. Dahl, PhD
Professor, Pharmacology, University of Wisconsin
on cancer pain initiatives in the US
10:30 - 11 a.m.
Discussion and coffee break
11 - 11:30 a.m.
Concluding Address
Nessa Coyle, MS, RN
Director of Supportive Care, Pain and Palliative Care Service, Memorial-Sloan-Kettering Cancer Center, New York
on opioids and pain management in the 21st century
11:30 - 12 noon
Closing discussion
12 noon
Adjournment
This program is supported by an unrestricted educational grant from Purdue Pharma L.P.
Registration Form
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Hotel Accommodations
Hotel room blocks have been reserved at three hotels within walking distance of the Faculty Center. In requesting reservations by fax or letter, specify that you will be attending the UCLA History of Pain Symposium.
[Note added 31 July for attendees who have not made their
reservations: Rooms and guaranteed conference rates cited below may no longer be available.]
DoubleTree Hotel
An excellent chain hotel with full meal and bar service and pool. Rooms with color TV and the usual amenities. Six blocks to conference facility;
hotel offers shuttle transport.
Address: 10740 Wilshire Blvd., Los Angeles 90024
FAX: 310/446-1723
Conference rates: $149 (single or double)
Hotel Del Capri
A charming oasis of suites with kitchenettes, color TV, and whirlpool baths. Pool; continental breakfast served all day. Six blocks to conference facility (uphill).
Address: 10587 Wilshire Blvd., Los Angeles 90024
FAX: 310/470-9999
Conference rate: $125 (suite) or $105 (guest room)
UCLA Guest House
Comfortable on-campus guest-house; all rooms with phone and TV. Continental breakfast served in the mornings. Five-minute walk to conference facility.
Address: 330 Charles Young Dr., Los Angeles 90095
FAX: 310/825-6108
Conference rate: $93 (single) or $98 (double room)
Refunds: A service charge of US $25 is withheld from all refunds (full refund if course is canceled, discontinued, or rescheduled). Refund requests must be post-marked by July 23, 2002. No refunds are given after the program begins unless specific exception is made. David Geffen School of Medicine, UCLA reserves the right to cancel the course, in which case a full refund is granted.
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