Nuclear Storage of Memory: An Idea Whose Time Has Come?

Tuesday, Jan 24, 2017 - 3:00pm to 4:30pm

The Jacob Marschak Interdisciplinary Colloquium on Mathematics in the Behavioral Sciences at UCLA

The idea that memy might be encoded as changes in the cell nucleus, particularly as alterations in DNA or RNA, has a long history. Currently, the synaptic model of memory storage predominates within neuroscience. However, recent evidence from studies of epigenetic changes associated with the storage of long-term memory has led to a renewed interest in the idea of nuclear storage of memory.

David Glanzman will present the results of recent experiments from his laboratory regarding the mechanisms of long-term memory in the model invertebrate oraganism Aplysia. These results indicate that the consolidation and maintenance of long-term memory depends critically on an epigenetic change, specifically, DNA methylation. In addition, Glanzman will describe how DNA methylation appears to regulate the occult persistence of memory after its apparent erasure, and discuss the implications of this discovery for treating disorders of memory.

Glanzman is a professor at UCLA in the departments of Integrative Biology and Physiology, and Neurobiology.

 

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